Detection of TP53/PIK3CA Mutations in Cell-Free Plasma DNA From Metastatic Breast Cancer Patients Using Next Generation Sequencing.

Chiaki Nakauchi,Naofumi Kagara,Kenzo Shimazu,Atsushi Shimomura,Yasuto Naoi,Masafumi Shimoda,Seung Jin Kim,Shinzaburo Noguchi

Clinical Breast Cancer（2016）

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摘要

These results suggest that mutations in ctDNA can be detected with next generation sequencing in MBC patients and could be a more useful prognostic factor for survival after recurrence than conventional tumor markers.

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关键词

Acquired mutation,Circulating tumor DNA,Liquid biopsy,Next generation sequencer,Prognostic biomarker

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