Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis.
Methods（2017）
摘要
•Donor derived isogenic models of tumorigenesis can be established in about 12weeks.•Allows comparison of cancer cells to their isogenic primary cells of origin.•Isogenic system needs to be engineered by each lab that wishes to use them.•Expression of RNA binding proteins are significantly altered during immortalization.•Post-transcriptional RNA dynamics are evident during tumor development.
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关键词
Post-transcriptional regulation,RNA binding proteins,RNA regulons,Tumorigenesis,Isogenic models
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