Domestic Pig Unlikely Reservoir For Mers-Cov

Emmie De Wit,Friederike Feldmann, Eva Horne,Cynthia Martellaro,Elaine Haddock,Trenton Bushmaker,Kyle Rosenke,Atsushi Okumura,Rebecca Rosenke,Greg Saturday,Dana Scott,Heinz Feldmann

EMERGING INFECTIOUS DISEASES（2017）

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摘要

We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.

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关键词

DPP4,MERS-CoV,Middle East respiratory syndrome coronavirus,United States,animal models,dipeptidyl peptidase 4,domestic pig,pigs,viruses,zoonoses

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