Preparation of well-defined brush-like block copolymers for gene delivery applications under biorelevant reaction conditions.

Joana R Góis, Fábio Reis,Ana M Almeida,Patrícia Pereira,Fani Sousa,Arménio C Serra,Jorge F J Coelho

Colloids and Surfaces B: Biointerfaces（2018）

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摘要

•Synthesis of well-defined bock copolymers under biorelevant reaction conditions.•Evaluation of block copolymers as non-viral gene vectors of plasmid DNA (pDNA).•Complexation of polymers with pDNA, high encapsulation efficiencies, no cytotoxicity.•Delivery of pDNA into nucleus of cervical cancer cells (in vitro experiments).

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关键词

SARA ATRP,Brush-like block copolymers,Gene delivery

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