Predictor Of Ga-68 Psma Pet/Ct Positivity In Patients With Prostate Cancer

BACKGROUND: The aim of this study was to evaluate predictive factors of (68)Gallium (Ga-68) prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) positivity.METHODS: Relationships between serum prostate specific antigen (PSA), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) levels, Gleason Score (GS) and positivity of Ga-68 PSMA PET in patients who underwent Ga-68 PSMA PET/CT for restaging for PCa were evaluated retrospectively.RESULTS: One hundred and four (median age: 67; range: 51-88) patients were included in this study. Of these patients. PSMA PET was positive in 75 (72%) patients. Mean scrum PSA levels for PET negative and positive groups were 0.76 +/- 1.00 and 180.85 +/- 324.93 ng/mL (P<0.001). The sensitivity and specificity of Ga-68 PSMA PET/CT for detection of disease recurrence were calculated as 92% and 80%, respectively, for the 1.4 ng/mL PSA cut-off and 92% and 90%. respectively, for the 2 ng/mL PSA cut-off values. The positivity rates for patients with PSA levels <1.4 ng/mL and >= 1.4 ng/mL were 21% and 90%, respectively (P<0.001).CONCLUSIONS: Ga-68 PSMA PET/CT seems to be a highly sensitive in patients with early PSA recurrence. Patients with higher GS and early PSA recurrence could benefit from Ga-68 PSMA PET/CT.