Multiplexed precision genome editing with trackable genomic barcodes in yeast

Kevin R Roy,Justin D Smith,Sibylle C Vonesch,Gen Lin,Chelsea Szu Tu,Alex R Lederer,Angela Chu,Sundari Suresh,Michelle Nguyen,Joe Horecka,Ashutosh Tripathi, Wallace T Burnett, Maddison A Morgan, Julia Schulz, Kevin M Orsley,Wu Wei,Raeka S Aiyar,Ronald W Davis,Vytas A Bankaitis,James E Haber,Marc L Salit,Robert P St.Onge,Lars M Steinmetz

NATURE BIOTECHNOLOGY（2018）

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摘要

method to introduce defined mutations into the yeast genome enables saturation mutagenesis of a gene and genome-scale introduction of genetic variants.

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关键词

Biological techniques,CRISPR-Cas9 genome editing,Genetics,Mutagenesis,Systems biology,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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