Impact of higher-order heme degradation products on hepatic function and hemodynamics.

Raphael A Seidel,Thierry Claudel,Franziska A Schleser,Navin K Ojha,Matthias Westerhausen,Sandor Nietzsche,Christoph Sponholz,Frans Cuperus,Sina M Coldewey,Stefan H Heinemann,Georg Pohnert,Michael Trauner,Michael Bauer

Journal of Hepatology（2017）

引用 17|浏览17

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摘要

•Plasma levels of bilirubin oxidation products rise in cholestatic liver disease.•The regio-isomers Z-BOX A and B exhibit distinct pharmacokinetics and -dynamics.•Z-BOX A and B differentially affect the hepatocellular glutathione redox state.•Z-BOX A and B differentially modulate the activity of Rev-erbα and Rev-erbβ.

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关键词

Heme degradation,Bilirubin oxidation end products (BOXes),Bilirubin toxicity,Rev-erb,Glutathione,Cholestasis,Hemodynamics,Pharmacokinetics,Cytoskeleton,Reactive oxygen species

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