Amorphous ternary nanoparticle complex of curcumin-chitosan-hypromellose exhibiting built-in solubility enhancement and physical stability of curcumin.

Li Ming Lim,The-Thien Tran,Jerome Jie Long Wong,Danping Wang,Wean Sin Cheow,Kunn Hadinoto

Colloids and Surfaces B: Biointerfaces（2018）

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摘要

•Amorphous ternary nanoplex of curcumin-chitosan-hypromellose is successfully formed.•Hypromellose addition produce larger nanoplex with lower zeta potential and payload.•Curcumin nanoplex with hypromellose has superior solubility enhancement.•Curcumin nanoplex with hypromellose is stable during long-term storage.•Curcumin nanoplex with hypromellose has minimal cytotoxicity to human gastric cells.

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ASD,AUC,C,CSat,CE,CHI,CUR,DLS,DSC,FESEM,FTIR,HPLC,HPMC,MHPMC/CHI,PXRD,RCHI/CUR,SGJ,SIJ,TGA,UV–vis,USP

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