Constant Quest for Quality: Digital Cytopathology.
Journal of pathology informatics(2018)
Abstract
BACKGROUND:Special consideration should be given when creating and selecting cytopathology specimens for digitization to maximize quality. Advances in scanning and viewing technology can also improve whole-slide imaging (WSI) output quality.
METHODS:Accumulated laboratory experience with digitization of glass cytopathology slides was collected.
RESULTS:This paper describes characteristics of a cytopathology glass slide that can reduce quality on resulting WSI. Important points in the glass cytopathology slide selection process, preparation, scanning, and WSI-editing process that will maximize the quality of the resulting acquired digital image are covered. The paper outlines scanning solutions which have potential to predict issues with a glass cytopathology slide before image acquisition, allowing for adjustment of the scanning approach. WSI viewing solutions that better simulate the traditional microscope experience are also discussed.
CONCLUSION:In addition to taking advantage of technical advances, practical steps can taken to maximize quality of cytopathology WSI.
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Key words
Cytopathology,digital pathology,quality assurance,virtual microscopy,virtual pathology,virtual slides,vslides,whole-slide imaging
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