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Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis

Hollie Burrell-Saward,Andrew J. Harris,Raul de LaFlor, Hatem Sallam,Mo S. Alavijeh,Theresa H. Ward,Simon L. Croft

International Journal of Antimicrobial Agents（2017）

Cited 12|Views8
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Abstract
•Dose dependent effect of fexinidazole against Trypanosoma brucei in a CNS mouse model of infection.•Time-kill effect of fexinidazole against Trypanosoma brucei in a CNS mouse model of infection.•The first use of microdialysis to measure drug and metabolite levels in the CNS in anti-trypanosomal drug development.
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Key words
Pharmacokinetics,Time–kill,Bioluminescence,Fexinidazole,Microdialysis,Trypanosoma brucei
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