Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice

Mathias J Friedrich,Lena Rad,Iraad F Bronner,Alexander Strong,Wei Wang,Julia Weber,Matthew Mayho,Hannes Ponstingl,Thomas Engleitner,Carolyn Grove,Anja Pfaus,Dieter Saur,Juan Cadiñanos,Michael A Quail,George S Vassiliou,Pentao Liu,Allan Bradley,Roland Rad

NATURE PROTOCOLS（2017）

引用 46|浏览70

暂无评分

摘要

Friedrich et al. describe their toolkit for transposon-based insertional mutagenesis in mice for discovering cancer genes. Genome-wide transposon insertion sites are identified, mapped and quantified using QiSeq.

查看译文

关键词

Cancer genetics,Cancer models,Mouse,Mutagenesis,Next-generation sequencing,Life Sciences,general,Biological Techniques,Analytical Chemistry,Microarrays,Computational Biology/Bioinformatics,Organic Chemistry

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要