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Preclinical pharmacokinetics of a recombinant humanized rabbit anti-VEGF monoclonal antibody in rabbits and monkeys.

Dong-An Yu,Meng You,Wan-Wan Ji,You Lu, Bin Liu,Shou-Sheng Yan

Toxicology Letters（2018）

Cited 5|Views4
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Abstract
•First humanized rabbit anti-VEGF monoclonal antibody used for eye diseases.•Quickly diffuse and distribute in ocular tissues.•Long half-life of TMAB001 in ocular tissues compared to some other drugs.
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Key words
Monoclonal antibody,TMAB001,Pharmacokinetics,Vascular endothelial growth factor
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