Turning Cold Tumors Hot by Blocking TGF-β
Trends in Cancer(2018)
Abstract
Novel immune therapeutic tools are rapidly expanding the anticancer arsenal. Despite this progress, patients with colorectal cancer (CRC) that spreads to vital parts of the body still have a dismal outcome. Transforming growth factor-beta (TGF-beta) plays a pivotal role in the development of CRC and metastasis. Important new work by Tauriello and colleagues has revealed that inhibition of TGF-beta prevents tumor metastasis by enhancing a cytotoxic T cell response, suggesting that TGF-beta inhibition is a promising pro-immunogenic therapy.
MoreTranslated text
Key words
colorectal cancer,metastasis,immunotherapy,CMS4,mesenchymal subtype,TGF-β
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined