[The Differentiation of Mesenchymal Stem Cells into Pacemaker-like Cells].

The biological pacemaker has become a new strategy in the treatment of severe bradycardias,in which a kind of ideal pacemaker cells is a pivotal factor.Here we reviewed the progress in the differentiation of bone-marrow mesenchymal stem cells and adipose-derived stem cells into pacemaker-like cells by means of gene transfer,chemical molecules,co-culture with other cells and specific culture media,and we also analyzed the potential issues to be solved when they are used as seeding cells of biological pacemaker.