MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis.

Olga Novosad, Tanya Skrypets,Yan Pastushenko, Iryna Titorenko,Arina Martynchyk,Oksana Skachkova, Mariia Inomistova, Alex Gorbach,Nataliia Khranovska,Irina Kryachok

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti（2018）

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摘要

BRAF and NRAS mutations in LCH suggest a possibility of the disease being driven by the activation of the MAPK/ERK pathway. These oncogenic mutations provide new opportunities in understanding LCH pathogenesis and may be a potential target of therapy.Key words: Langerhans cell histiocytosis - mutations - prognostic factors - relapse - survival.

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