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Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Liriye Kurtovic,Marije C. Behet,Gaoqian Feng,Linda Reiling,Kiprotich Chelimo,Arlene E. Dent,Ivo Mueller,James W. Kazura,Robert W. Sauerwein,Freya J. I. Fowkes,James G. Beeson

BMC Medicine（2018）

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Abstract
Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity.
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Key words
Antibodies,Circumsporozoite protein,Sporozoite,Complement,Malaria,Plasmodium falciparum,Vaccines
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