Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
BMC Medicine(2018)
Abstract
Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity.
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Key words
Antibodies,Circumsporozoite protein,Sporozoite,Complement,Malaria,Plasmodium falciparum,Vaccines
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