Successful proof of concept of a micronucleus genotoxicity assay on reconstructed epidermis exhibiting intrinsic metabolic activity.

•We evaluated the performance of a new in vitro assay for genotoxicity.•The Episkin LM™ model was found as suitable for this assay.•The prediction performances were evaluated for the detection of known genotoxins.•The ability of Episkin LM™ model to bioactivate progenotoxins was established.