Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model.

Ke Liu,Changguang Xiao,Feifei Wang,Xiao Xiang,Anni Ou,Jianchao Wei,Beibei Li,Donghua Shao,Denian Miao,Fanfan Zhao,Gang Long,Yafeng Qiu,Huaimin Zhu,Zhiyong Ma

Cytokine（2018）

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摘要

•Dynamic profile of chemokines and histochemistry of brain in JEV infected mice.•CCR5 and CCR2 related chemokines contribute to major inflammatory response.•CCR5 and CCR2 antagonist reduce the inflammation and raise the survival.

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关键词

Inflammation related genes,Chemokines,Japanese encephalitis virus

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