Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands.

Jiřina Procházková,Simona Strapáčová,Lucie Svržková,Zdeněk Andrysík,Martina Hýžďalová,Eva Hrubá,Kateřina Pěnčíková,Helena Líbalová,Jan Topinka,Jiří Kléma,Joaquín M Espinosa,Jan Vondráček,Miroslav Machala

Toxicology Letters（2018）

引用 19|浏览27

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摘要

•Global gene profiling of AhR-dependent changes in lung cancer cells transcriptome.•Acute exposure to TCDD, BaP, BkF, ITE and FICZ shows common expression fingerprint.•Suggestion of specific novel cellular candidates for monitoring of TCDD exposure.•GREM1, HIPK2, SOX9, ID1 proposed as novel gene sensors of AhR activity in lung cells.•Prediction of activation status of pathways/processes during acute TCDD exposure.

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关键词

Aryl hydrocarbon receptor,Lung cancer,Dioxins,Global gene expression profiling

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