Repeated propofol anesthesia induced downregulation of hippocampal miR-132 and learning and memory impairment of rats.
Brain Research(2017)
摘要
•Propofol causes sequential changes of miR-132 and its related protein of hippocampus.•Neonatal exposure to propofol causes neurodevelopmental damage.•Propofol causes a decrease in the number of dendritic spines in the hippocampus.
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关键词
Propofol,Anesthesia,miR-132,Neurotoxicity,Hippocampus
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