Individual, peer, and family factor modification of neighborhood-level effects on adolescent alcohol, cigarette, e-cigarette, and marijuana use.

•Neighborhood alcohol/drug problems are associated with alcohol and marijuana use.•Higher neighborhood disorganization is associated with higher odds of substance use.•Parental monitoring did not modify effects of neighborhood quality.•More affiliation with peers who use exacerbated poor quality neighborhood effects.•Resistance self-efficacy may curb substance use for youth in unsafe neighborhood.