Thiotepa Based Intensified Reduced-Intensity Conditioning Adult Double-Unit Cord Blood Hematopoietic Stem Cell Transplantation Results in Decreased Relapse Rate and Improved Survival Compared to Transplantation Following Standard Reduced-Intensity Conditioning: a Retrospective Cohort Comparison.

•We compared transplant-related outcomes following double-unit CBT in those who received standard RIC versus thiotepa-based intensified RIC.•There was decreased relapse rate and improved OS in patients receiving intensified RIC without increase in TRM.•Based on this analysis, we suggest consideration of an intensified thiotepa-based RIC regimen in fit, older patients undergoing CBT who would have otherwise received standard RIC in the past.