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Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus

Dan Shan, Shouguo Fang,Zongxi Han,Hui Ai,Wenjun Zhao,Yuqiu Chen,Lei Jiang,Shengwang Liu

Virus Research（2018）

Cited 30|Views26
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Abstract
•For the first time using reverse genetics to reveal the roles of HVRs in coronavirus.•The HVRs exchange from IBV S1 subunit weakened the adsorption during IBV infection in vitro.•The HVRs exchange in IBV S1 reduced ARV with Beaudette, but not sufficiently change serotypes.•The recombinant IBVs provided insights into reverse genetic vaccines.
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Key words
Hypervariable region,Infectious bronchitis virus,Infectious clone,Recombinant IBV,Reverse genetic vaccine
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