Systematic review and meta-analysis of the prognostic significance of microRNAs in cervical cancer.

In this meta-analysis, we analyzed case-control studies that assessed the prognostic potential of miRNAs in cervical cancer. We comprehensively searched EMBASE and PubMed databases and enrolled seven studies with 445 cervical cancer cases. A fixed effects model was used to calculate pooled hazard ratios (HRs) and associated 95% confidence intervals (95% CIs) from the overall survival (OS) data. Our analysis showed that poor OS in cervical cancer was associated with low miR-125 expression (HR = 1.61, 95% CI: 1.02-2.55, = 0.042; I = 10.1%, = 0.292; = 99), low miR-145 expression (HR = 1.70, 95% CI: 1.29-2.24, < 0.001; I = 0%, = 0.560; = 193) and high miR-196 expression (HR = 0.28, 95% CI: 0.15-0.52, < 0.001; I = 0%, = 0.950, = 197). This makes microRNAs such as miR-125, miR-145 and miR-196 potential prognostic biomarkers in cervical cancer.