Process intensification of core streptavidin production through high-cell-density cultivation of recombinant E. coli and a temperature-based refolding method.

Leong Huat Chua,Soo Choon Tan,Mervyn W O Liew

Journal of Biotechnology（2018）

引用 9|浏览20

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摘要

•Intensified process developed for cSAV production.•Volumetric yield improved by 36-fold through high-cell-density cultivation.•Refolding yield improved by 8–16% through temperature-based method.•High quality cSAV was obtained.

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关键词

Escherichia coli,High-cell-density cultivation,Temperature-based refolding,Core streptavidin,Process intensification

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