Design, synthesis, evaluation, and molecular docking of ursolic acid derivatives containing a nitrogen heterocycle as anti-inflammatory agents.

In an attempt to develop novel and potent anti-inflammatory agents, four novel series of ursolic acid derivatives containing oxadiazole, triazolone and piperazine moieties were designed, synthesized, and evaluated for anti-inflammatory activity. The cytotoxicity and molecular docking studies of these compounds was also assessed.