Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell

David Lando,Srinjan Basu,Tim J Stevens,Andy Riddell,Kai J Wohlfahrt, Yang Cao,Wayne Boucher,Martin Leeb,Liam P Atkinson,Steven F Lee,Brian Hendrich,Dave Klenerman,Ernest D Laue

NATURE PROTOCOLS（2018）

引用 13|浏览27

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摘要

This protocol shows how to combine fluorescence imaging with single-cell Hi-C, to study genome architecture in single cells with high resolution.

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关键词

Cellular imaging,Chromatin analysis,Chromatin structure,Chromosomes,Nuclear organization,Life Sciences,general,Biological Techniques,Analytical Chemistry,Microarrays,Computational Biology/Bioinformatics,Organic Chemistry

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