Electroconvulsive seizures influence dendritic spine morphology and BDNF expression in a neuroendocrine model of depression

Kristen. R. Maynard,John W. Hobbs,Sumita K. Rajpurohit,Keri Martinowich

Brain Stimulation（2018）

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摘要

•Stress-induced depression causes dendritic spine atrophy in the cortex.•We hypothesize that electroconvulsive seizures (ECS) reverse spine defects.•The hypothesis is tested in a neuroendocrine model of depression in mice.•ECS rescues stress-induced spine morphology changes on pyramidal neurons.•ECS elevates specific isoforms of brain-derived neurotrophic factor (BDNF).

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关键词

Brain-derived neurotrophic factor (BDNF),Electroconvulsive seizures,ECT,Dendritic spine,Cingulate cortex,Morphology

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