Allergic patients with and without allergen-specific immunotherapy mount protective immune responses to tick-borne encephalitis vaccination in absence of enhanced side effects or propagation of their Th2 bias.

•TBE antibody titers are comparable between allergic and healthy subjects.•Specific immunotherapy does not limit protective TBE vaccine responses.•Vaccinating allergic patients does not propagate Th2 immune responses or allergic symptoms.•Allergic and healthy subjects have similar reactogenicity profiles.•No indication to postpone vaccinations in allergic patients, even under SIT.