Detoxification Process Of Tolaasins, Lipodepsipeptides, By Microbacterium Sp K3-5

Shun Tomita,Masayuki Sue,Akinobu Kajikawa,Shizunobu Igimi,Hirosuke Shinohara,Kenji Yokota

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2018）

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摘要

Tolaasins are antimicrobial lipodepsipeptides. Here, we report the tolaasins-detoxifying properties of Microbacterium sp. K3-5 (K3-5). The detoxification of tolaasins by K3-5 was performed by hydrolyzation of cyclic structure of tolaasins depending on the tolaasin-K3-5 cell interaction. Our data suggest that the cyclic structure of tolaasins is critical for its interaction to target cells.

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关键词

Tolaasin, Pseudomonas tolaasii, Microbacterium sp, lipodepsipeptide, antifungal activity

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