Identification of nonsynonymous TP53 mutations in hydatidiform moles

Ka-Kui Chan,Esther Shuk-Ying Wong,Oscar Gee-Wan Wong,Hextan Yuen-Sheung Ngan,Annie Nga-Yin Cheung

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2018）

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摘要

•Pyrosequencing detects the nonsynonymous TP53 mutations which have been overlooked in hydatidiform mole before.•A small population of cells in hydatidiform mole harbors TP53 mutations.•A more thorough analysis on TP53 mutation might be useful to understand the pathogenesis of hydatidiform mole.

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关键词

Hydatidiform mole,Pyrosequencing,TP53 mutation

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