Novel Insights for Inhibiting Mutant Heterodimer IDH1 in Cancer: An In-Silico Approach.

BackgroundIsocitrate dehydrogenase 1 (IDH1) is a dimeric enzyme responsible for supplying the cell’s nicotinamide adenine dinucleotide phosphate (NADPH) reserves via dehydrogenation of isocitrate (ICT) and reduction of NADP+. Mutations in position R132 trigger cancer by enabling IDH1 to produce d-2-hydroxyglutarate (2-HG) and reduce inhibition by ICT. Mutant IDH1 can be found as a homodimer or a heterodimer.