Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity.
Molecular Metabolism(2018)
Abstract
•DMH GLP-1R stimulation acutely increases BAT thermogenesis.•DMH GLP-1R mRNA knockdown decreases EE and BAT thermogenesis.•DMH GLP-1R mRNA knockdown impairs lipid and glucose metabolism.•Reduced DMH GLP-1R signaling blunts the anorexigenic responses to Ex-4.•DMH GLP-1R signaling indirectly regulates NPY gene expression.
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Key words
Neuropeptide,Hypothalamus,Sympathetic nerve,Adipose tissue,Obesity
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