Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Kristy Ou,Jia Zhang,Yang Jiao,Zhao V Wang,Phillipp Scherer,Klaus H Kaestner

Molecular Metabolism（2018）

Cited 3|Views20

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Abstract

•Hypothesized that overexpression of ST5 would drive adult β-cell proliferation due to its role in activating MAPK/ERK.•Generated a doxycycline-inducible bitransgenic mouse model to activate β-cell-specific expression of ST5.•ST5 overexpression has no mitogenic effect on adult β-cellsunder basal and metabolically challenged states.

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Key words

Diabetes,β-cell proliferation,ST5 (Suppression Of Tumorigenicity 5),Ras/ERK signaling

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