Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis

Hanna Köchling,Katrin Schaper,Jenny Wilzopolski,Ralf Gutzmer,Thomas Werfel,Wolfgang Bäumer,Manfred Kietzmann,Kristine Rossbach

Journal of Dermatological Science（2017）

引用 17|浏览5

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摘要

•Combination of H1R and H4R antagonist shows synergistic anti-inflammatory action.•Combined treatment reduces ovalbumin-induced skin lesions and pruritus in mice.•H1R plus H4R antagonists reduce epidermal thickening and IL-33 in lesional skin.

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关键词

AD,EASI,H1R,H4R,OVA

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