Process Chemistry in Antiviral Research

Yong-Li Zhong,Nobuyoshi Yasuda,Hongming Li,Mark McLaughlin,David Tschaen

Topics in current chemistry (Cham)（2016）

引用 5|浏览30

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摘要

This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process chemistry that enabled access to these important drugs. In particular, process chemistry highlights from the practical syntheses of the HCV drugs sofosbuvir (Gilead), grazoprevir (Merck), and elbasvir (Merck), the HIV therapy darunavir (Tibotec) and the influenza treatment peramivir (BioCryst) are presented.

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关键词

Antivirals,Asymmetric synthesis,Darunavir,Elbasvir,Grazoprevir,HCV,HIV,Influenza,Peramivir,Practical synthesis,Process chemistry,Sofosbuvir

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