Skeletal muscle water T 2 as a biomarker of disease status and exercise effects in patients with Duchenne muscular dystrophy.

Ami Mankodi,Noura Azzabou,Thomas Bulea,Harmen Reyngoudt,Hirity Shimellis,Yupeng Ren,Eunhee Kim,Kenneth H Fischbeck,Pierre G Carlier

Neuromuscular Disorders（2017）

引用 32|浏览30

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摘要

•Triexponential method measures muscle water T2 in fatty-infiltrated muscles in DMD.•Muscle water T2 is a useful biomarker of disease status in clinical trials of DMD.•Muscle water T2 is responsive to exercise effects in DMD subjects as in controls.

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关键词

Duchenne muscular dystrophy,Magnetic resonance imaging,Exercise,Skeletal muscle,Fat fraction,Water T2

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