Pre- vs. post-treatment with melatonin in CCl 4 -induced liver damage: Oxidative stress inferred from biochemical and pathohistological studies.

In conclusion, melatonin, especially as a post-intoxication treatment, attenuated CCl-induced liver oxidative damage, increased liver antioxidant capacities and improved liver microscopic appearance. The results are of interest due to the great protective potential of melatonin that was even demonstrated to be stronger if applied after the tissue damage.