The Loss of p21-Activated Kinase (Pak1) Promotes Atrial Arrhythmic Activity The Role of Pak1 in Atrial Arrhythmia.

Heart Rhythm(2018)

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摘要
The experiments support that Pak1 stimulation can attenuate NCX-dependent Ca overload and prevent triggered arrhythmic activity by suppressing NOX2-dependent ROS production.
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关键词
Atrial fibrillation,Excitation-contraction coupling,NADPH oxidase-2,p21-activated kinase,Reactive oxygen species
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