Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Christopher J. Helal,Eric P. Arnold,Tracey L. Boyden,Cheng Chang,Thomas A. Chappie,Kimberly F. Fennell,Michael D. Forman,Mihaly Hajos,John F. Harms,William E. Hoffman,John M. Humphrey,Zhijun Kang,Robin J. Kleiman,Bethany L. Kormos,Che-Wah Lee,Jiemin Lu,Noha Maklad,Laura McDowell,Scot Mente,Rebecca E. O'Connor,Jayvardhan Pandit,Mary Piotrowski,Anne W. Schmidt,Christopher J. Schmidt,Hirokazu Ueno,Patrick R. Verhoest,Edward X. Yang Journal of Medicinal Chemistry（2017）
关键词
Compartmentalized Signaling
AI 理解论文
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