Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury.

Candela Diaz-Cañestro,Mario Merlini,Nicole R Bonetti,Luca Liberale,Patricia Wüst,Sylvie Briand-Schumacher,Jan Klohs,Sara Costantino,Melroy Miranda,Gabriele Schoedon-Geiser,Gerd A Kullak-Ublick,Alexander Akhmedov,Francesco Paneni,Jürg H Beer,Thomas F Lüscher,Giovanni G Camici

International Journal of Cardiology（2018）

引用 62|浏览23

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摘要

•SIRT5−/− mice display decreased stroke size and neurological deficits after stroke.•SIRT5−/− mice present reduced BBB leakage and occludin degradation.•SIRT5 silencing increases endothelial resistance and TJPs in HBMVECs.•SIRT5 gene expression increases in PBMCs of AIS patients.

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关键词

SIRT5,Blood-brain barrier,Tight junction proteins,PI3K/Akt pathway

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