In Vitro Combination Of Voriconazole With Micafungin Against Azole-Resistant Clinical Isolates Of Aspergillus Fumigatus From Different Geographical Regions

H. Fakhim,A. Vaezi,E. Dannaoui,C. Sharma,B. Mousavi, E. Nasri,A. Chowdhary,J. F. Meis,H. Badali

MEDICAL MYCOLOGY（2018）

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Abstract

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and -susceptible (n=2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR34/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.

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