One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2‑(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols
Organic Letters(2018)
Abstract
A novel approach for the synthesis of indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under the solvent- and metal-free conditions has provided a straightforward path to construct indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, and high efficiency.
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Key words
indolizines,synthesis,ynals,one-pot,solvent-free,metal-free,three-component
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