Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies.
Journal of Pharmaceutical and Biomedical Analysis（2018）
Abstract
•An UHPLC–MS/MS method for simultaneous determination of 8 tyrosine kinase inhibitors (TKIs) was developed and validated.•The robust and sensitive method was successfully applied in a pharmacokinetic study in mice.•The method can be expandable to the measurement of other TKIs.
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Key words
Tyrosine kinase inhibitors,UHPLC–MS/MS,Mice pharmacokinetics
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