Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation.

C Manferdini,F Paolella,E Gabusi,L Gambari,A Piacentini,G Filardo,S Fleury-Cappellesso,A Barbero,M Murphy,G Lisignoli

Osteoarthritis and Cartilage（2017）

Cited 98|Views1

No score

Abstract

We demonstrated that ASC are responsible for the switching of activated-M1-like inflammatory macrophages to a M2-like phenotype, mainly through PGE2. This evidenced that activated-M1-like macrophages may represent a relevant cell model to test the efficacy/potency of ASC and suggests a specific role of ASC as important determinants in therapeutic dampening of synovial inflammation in OA.

Translated text

Key words

Synovitis,Adipose mesenchymal stromal cells,Monocytes/macrophages,Inflammation,Osteoarthritis

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined