L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation.
Brain, Behavior, and Immunity（2017）
Abstract
•De novo L1 insertions occur in the adult hippocampus after exploration.•Blocking hippocampal L1 retrotransposition events prevents long-term memory formation.•Hippocampal L1 activity enables for long-term memory consolidation.
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Key words
Memory formation,LINE1,Retrotransposition,Gene expression,Hippocampus
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