New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins.

Patrique Praest,A Manuel Liaci,Friedrich Förster,Emmanuel J H J Wiertz

Molecular Immunology（2019）

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摘要

•The molecular composition of the MHC I peptide loading complex is delineated.•Important structural aspects of the TAP peptide transport cycle are summarized.•Novel data on the viral TAP inhibitors ICP47 and CPXV012 are discussed.

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关键词

MHC class I,TAP,Antigen presentation,Viral immune evasion,Peptide loading complex,Herpesvirus

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