Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy. Nobuhiro Suzumori , Akihiko Sekizawa , Takeshi Ebara , Osamu Samura , Aiko Sasaki , Rina Akaishi , Seiji Wada , Haruka Hamanoue , Fumiki Hirahara , Haruna Izumi , Hideaki Sawai , Hiroaki Nakamura , Takahiro Yamada , Kiyonori Miura , Hideaki Masuzaki , Takahiro Yamashita , Takashi Okai , Yoshimasa Kamei , Akira Namba , Jun Murotsuki , Tomohiro Tanemoto , Akimune Fukushima , Kazufumi Haino , Shinya Tairaku , Keiichi Matsubara , Kazutoshi Maeda , Takashi Kaji , Masanobu Ogawa , Hisao Osada , Haruki Nishizawa , Yoko Okamoto , Takeshi Kanagawa , Aiko Kakigano , Michihiro Kitagawa , Masaki Ogawa , Shunichiro Izumi , Yukiko Katagiri , Naoki Takeshita , Yasuyo Kasai , Katsuhiko Naruse , Reiko Neki , Hisashi Masuyama , Maki Hyodo , Yukie Kawano , Takashi Ohba , Kiyotake Ichizuka , Takeshi Nagamatsu , Atsushi Watanabe , Nahoko Shirato , Junko Yotsumoto , Miyuki Nishiyama , Tatsuko Hirose , Haruhiko Sago European Journal of Obstetrics & Gynecology and Reproductive Biology（2018）
Abstract
A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.
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Key words
Cell-free DNA, Fetal fraction, HDP, NIPT, Prenatal diagnosis
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