Intranasal administration of sodium dimethyldithiocarbamate induces motor deficits and dopaminergic dysfunction in mice.

Josiel M Mack, Tainara M Moura,Débora Lanznaster,Franciane Bobinski,Caio M Massari,Tuane B Sampaio,Ariana E Schmitz,Luiz F Souza,Roger Walz,Carla I Tasca,Anicleto Poli,Richard L Doty,Alcir L Dafre,Rui D Prediger

NeuroToxicology（2018）

引用 11|浏览4

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摘要

•Intranasal infusions of NaDMDC induced motor and neurological deficits in mice.•Intranasal infusions of NaDMDC increased striatal TH immunocontent and dopamine degradation.•Anti-parkinsonian drugs l-DOPA and apomorphine improved the NaDMDC-induced locomotor deficits.•Intranasal infusions of NaDMDC increased ROS levels in the olfactory bulb and striatum of mice.

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关键词

Parkinson’s disease,Intranasal,Olfactory pathway,Dimethyldithiocarbamate,NaDMDC,Motor deficits,Mice

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