Macrophage regulation of B cell proliferation.
Cellular Immunology（2017）
Abstract
•Peritoneal cell culture models macrophage-rich tumor microenvironments (TMEs).•Cyclooxygenase and IL10 suppress B cells activated by BCR and TLR-4 ligation.•Cultured peritoneal cavity B cells respond to CD40 ligation.•CD40 ligation enhanced BCR or TLR-4 responses but was suppressed by concurrent TCR ligation.
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Key words
APC,ARG,COX,IDO,INDO,iNOS,PerC,ROS,SP,1-MA,1-MT,1-NA
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